Microarray probe selection strategies

Dissociation Analysis for Microarray Probe Selection

1 Molecular Biotechnology  2005 Humana Press Inc. All rights of any nature whatsoever reserved. 1073–6085/2005/29:1/01–10/$30.00 *Author to whom all correspondence and reprint requests should be addressed. Agroscope FAW Waedenswil, Swiss Federal Research Station for Horticulture, Department of Crop Protection, Laboratory for Molecular Diagnostics, CH-8820 Waedenswil, Switzerland. E-mail: monik...

Randomized probe selection algorithm for microarray design.

DNA microarray technology, originally developed to measure the level of gene expression, has become one of the most widely used tools in genomic study. The crux of microarray design lies in how to select a unique probe that distinguishes a given genomic sequence from other sequences. Due to its significance, probe selection attracts a lot of attention. Various probe selection algorithms have be...

Strategies for enhanced annotation of a microarray probe set

We aim to determine the biological relevance of genes identified through microarray-mediated transcriptional profiling of Xenopus sensory organs and brain. Difficulties with genetic data analysis arise because of limitations in probe set annotation and the lack of a universal gene nomenclature. To overcome these impediments, we used sequence based and semantic linking methods in combination wit...

Algorithms for probe selection and DNA microarray design

Probe selection for pathway-specific microarray probe design minimizing melting temperature variance

In molecular biology, microarray technology is widely and successfully utilized to efficiently measure gene activity. If working with less studied organisms, methods to design custom-made microarray probes are available. One design criterion is to select probes with minimal melting temperature variances thus ensuring similar hybridization properties. If the microarray application focuses on the...